Improvement of health-related quality of life and psychological well-being after HCV eradication with direct-acting antiviral agents. Real life setting data of an Italian cohort valued by Hepatitis Quality of Life Questionnaire (HQLQv2)

HCV (Hepatitis C Virus) decreases Health-Related Quality of Life with detriments to physical, mental and social health domains. Interferon Ribavirin treatment is associated depression anxiety that further impairs HRQoL (Health- Related Life). IFN-free (interferon-free) regimes (Direct Acting Antivirals, DAAs) are safe highly effective drugs, improvement also related Psychological Well-Being. Our aim describe how the latest generation can change quality life Well-Being in Italian Chronic Hepatitis C/Cirrhosis affected patients. SF-36v2 (Short Form Health Survey a 36-item, patient-reported survey patient health) – HQLQv2 Questionnaire) was administered at two time points: baseline (n=72) 12 weeks after end therapy [n=72, SVR=72 - Sustained Virologic Response (SVR)]. Patients chronic undergoing DAAs from centers were enrolled. The overall average answers configured for most domains make up questionnaire, scores above 50. this sample very close US population, minimum score 45.9 Role Emotional scale an maximum 56.4 Vitality scale. Both significant results statistical analysis. It seems does not affect but improves general psychological state adult patients infection.